Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

T M  Gloster; S J  Williams; S  Roberts; C A  Tarling; J  Wicki; S G  Withers; G J  Davies

doi:10.1039/b405152a

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

T M Gloster, S J Williams, S Roberts, C A Tarling, J Wicki, S G Withers, G J Davies

Research output: Contribution to journal › Article › peer-review

Abstract

The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

Original language	English
Pages (from-to)	1794-1795
Number of pages	2
Journal	Chemical Communications
Issue number	16
DOIs	https://doi.org/10.1039/b405152a
Publication status	Published - 2004

Keywords

GLYCOSIDASE INHIBITOR
STATE

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10.1039/b405152a

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title = "Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A",

abstract = "The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.",

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author = "Gloster, \{T M\} and Williams, \{S J\} and S Roberts and Tarling, \{C A\} and J Wicki and Withers, \{S G\} and Davies, \{G J\}",

year = "2004",

doi = "10.1039/b405152a",

language = "English",

pages = "1794--1795",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "16",

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TY - JOUR

T1 - Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

AU - Gloster, T M

AU - Williams, S J

AU - Roberts, S

AU - Tarling, C A

AU - Wicki, J

AU - Withers, S G

AU - Davies, G J

PY - 2004

Y1 - 2004

N2 - The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

AB - The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

KW - GLYCOSIDASE INHIBITOR

KW - STATE

UR - https://www.scopus.com/pages/publications/4644286997

U2 - 10.1039/b405152a

DO - 10.1039/b405152a

M3 - Article

SN - 1359-7345

SP - 1794

EP - 1795

JO - Chemical Communications

JF - Chemical Communications

IS - 16

ER -

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

Abstract

Keywords

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