Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

T M  Gloster; S J  Williams; S  Roberts; C A  Tarling; J  Wicki; S G  Withers; G J  Davies

doi:10.1039/b405152a

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

T M Gloster, S J Williams, S Roberts, C A Tarling, J Wicki, S G Withers, G J Davies

Research output: Contribution to journal › Article › peer-review

Abstract

The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

Original language	English
Pages (from-to)	1794-1795
Number of pages	2
Journal	Chemical Communications
Issue number	16
DOIs	https://doi.org/10.1039/b405152a
Publication status	Published - 2004

Keywords

GLYCOSIDASE INHIBITOR
STATE

Access to Document

10.1039/b405152a

Cite this

@article{e83cbcce300945bcb909e802b846b0bc,

title = "Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A",

abstract = "The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.",

keywords = "GLYCOSIDASE INHIBITOR, STATE",

author = "Gloster, {T M} and Williams, {S J} and S Roberts and Tarling, {C A} and J Wicki and Withers, {S G} and Davies, {G J}",

year = "2004",

doi = "10.1039/b405152a",

language = "English",

pages = "1794--1795",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "16",

}

TY - JOUR

T1 - Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

AU - Gloster, T M

AU - Williams, S J

AU - Roberts, S

AU - Tarling, C A

AU - Wicki, J

AU - Withers, S G

AU - Davies, G J

PY - 2004

Y1 - 2004

N2 - The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

AB - The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

KW - GLYCOSIDASE INHIBITOR

KW - STATE

U2 - 10.1039/b405152a

DO - 10.1039/b405152a

M3 - Article

SN - 1359-7345

SP - 1794

EP - 1795

JO - Chemical Communications

JF - Chemical Communications

IS - 16

ER -

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

Abstract

Keywords

Access to Document

Fingerprint

Cite this