Asymmetric synthesis of homochiral Baylis-Hillman products employing (R)-N-methyl-N-α-methylbenzyl amide

Stephen G. Davies; Christian A.P. Smethurst; Andrew D. Smith; G. Darren Smyth

doi:10.1016/S0957-4166(00)00224-X

Asymmetric synthesis of homochiral Baylis-Hillman products employing (R)-N-methyl-N-α-methylbenzyl amide

Stephen G. Davies^*
, Christian A.P. Smethurst
, Andrew D. Smith
, G. Darren Smyth

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The conjugate addition of (R)-N-methyl-N-α-methylbenzyl amide to tert-butyl cinnamate followed by an asymmetric aldol reaction and subsequent N-oxidation/Cope elimination affords β-substituted homochiral Baylis-Hillman products in good yield. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2437-2441
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	11
Issue number	12
DOIs	https://doi.org/10.1016/S0957-4166(00)00224-X
Publication status	Published - 30 Jun 2000

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title = "Asymmetric synthesis of homochiral Baylis-Hillman products employing (R)-N-methyl-N-α-methylbenzyl amide",

abstract = "The conjugate addition of (R)-N-methyl-N-α-methylbenzyl amide to tert-butyl cinnamate followed by an asymmetric aldol reaction and subsequent N-oxidation/Cope elimination affords β-substituted homochiral Baylis-Hillman products in good yield. Copyright (C) 2000 Elsevier Science Ltd.",

author = "Davies, \{Stephen G.\} and Smethurst, \{Christian A.P.\} and Smith, \{Andrew D.\} and Smyth, \{G. Darren\}",

year = "2000",

month = jun,

day = "30",

doi = "10.1016/S0957-4166(00)00224-X",

language = "English",

volume = "11",

pages = "2437--2441",

journal = "Tetrahedron Asymmetry",

issn = "0957-4166",

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T1 - Asymmetric synthesis of homochiral Baylis-Hillman products employing (R)-N-methyl-N-α-methylbenzyl amide

AU - Davies, Stephen G.

AU - Smethurst, Christian A.P.

AU - Smith, Andrew D.

AU - Smyth, G. Darren

PY - 2000/6/30

Y1 - 2000/6/30

N2 - The conjugate addition of (R)-N-methyl-N-α-methylbenzyl amide to tert-butyl cinnamate followed by an asymmetric aldol reaction and subsequent N-oxidation/Cope elimination affords β-substituted homochiral Baylis-Hillman products in good yield. Copyright (C) 2000 Elsevier Science Ltd.

AB - The conjugate addition of (R)-N-methyl-N-α-methylbenzyl amide to tert-butyl cinnamate followed by an asymmetric aldol reaction and subsequent N-oxidation/Cope elimination affords β-substituted homochiral Baylis-Hillman products in good yield. Copyright (C) 2000 Elsevier Science Ltd.

UR - https://www.scopus.com/pages/publications/0034733512

U2 - 10.1016/S0957-4166(00)00224-X

DO - 10.1016/S0957-4166(00)00224-X

M3 - Article

AN - SCOPUS:0034733512

SN - 0957-4166

VL - 11

SP - 2437

EP - 2441

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 12

ER -

Asymmetric synthesis of homochiral Baylis-Hillman products employing (R)-N-methyl-N-α-methylbenzyl amide

Abstract

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