Asymmetric synthesis of 2-alkyl- And 2-aryl-3-aminopropionic acids (β2-amino acids) from (S)-N-acryloyl-5,5-dimethyloxazolidin-2- one SuperQuat derivatives

James E. Beddow, Stephen G. Davies*, Andrew D. Smith, Angela J. Russell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Conjugate addition of lithium amides to (S)-N-acryloyl- or (S)-N-2′-alkylacryloyloxazolidinones and alkylation or protonation of the resulting enolates with 2-pyridone respectively provides a highly stereoselective and product complementary route to a range of (R)- and (S)-2-alkyl-3-aminopropionic acids in good yield and in high ee.

Original languageEnglish
Pages (from-to)2778-2779
Number of pages2
JournalChemical Communications
Issue number23
DOIs
Publication statusPublished - 7 Dec 2004

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