Asymmetric synthesis of β-haloaryl β-amino acid derivatives

Steven D. Bull, Stephen G. Davies*, Santiago Delgado-Ballester, Peter M. Kelly, Luke J. Kotchie, Massimo Gianotti, Mario Laderas, Andrew D. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Lithium N-benzyl-N-α-methyl-4-methoxybenzylamide may be employed as a homochiral ammonia equivalent for the synthesis of homochiral β-haloaryl β-amino acid derivatives via a strategy involving its conjugate addition to α,β-unsaturated β-haloaryl acceptors and subsequent oxidative deprotection with ceric ammonium nitrate.

Original languageEnglish
Pages (from-to)3112-3121
Number of pages10
JournalJournal of the Chemical Society. Perkin Transactions 1
Issue number23
Publication statusPublished - 16 Nov 2001


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