Abstract
The diastereoselective conjugate addition of lithium (R)-N-benzyl-N-α-methylbenzylamide to α,β-unsaturated esters and subsequent enolate hydroxylation, followed by reduction and oxidative cleavage provides a facile route to N,N-protected α-amino aldehydes and ketones. Further manipulation furnishes α-amino acids in high enantiomeric excess.
Original language | English |
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Pages (from-to) | 1599-1601 |
Number of pages | 3 |
Journal | Synlett |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Jan 2001 |
Keywords
- Asymmetric synthesis
- Conjugate addition
- Lithium amides
- α-amino acid
- α-amino aldehyde
- β-amino acids