Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

Edward Richmond; Nicolas Duguet; Alexandra M. Z. Slawin; Tomas Lebl; Andrew D. Smith

doi:10.1021/ol300982f

Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

Edward Richmond, Nicolas Duguet, Alexandra M. Z. Slawin, Tomas Lebl, Andrew D. Smith

Research output: Contribution to journal › Article › peer-review

Abstract

The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.

Original language	English
Pages (from-to)	2762-2765
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	11
DOIs	https://doi.org/10.1021/ol300982f
Publication status	Published - 1 Jun 2012

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title = "Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles",

abstract = "The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.",

author = "Edward Richmond and Nicolas Duguet and Slawin, {Alexandra M. Z.} and Tomas Lebl and Smith, {Andrew D.}",

year = "2012",

month = jun,

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doi = "10.1021/ol300982f",

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journal = "Organic Letters",

issn = "1523-7060",

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T1 - Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

AU - Richmond, Edward

AU - Duguet, Nicolas

AU - Slawin, Alexandra M. Z.

AU - Lebl, Tomas

AU - Smith, Andrew D.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.

AB - The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.

U2 - 10.1021/ol300982f

DO - 10.1021/ol300982f

M3 - Article

SN - 1523-7060

VL - 14

SP - 2762

EP - 2765

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

Abstract

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