ASYMMETRIC ADDITION OF ORGANOMETALLIC REAGENTS TO O-PHENETHYL ALDOXIMES

P T  GALLAGHER; A P  LIGHTFOOT; C J  MOODY; A M Z  SLAWIN

ASYMMETRIC ADDITION OF ORGANOMETALLIC REAGENTS TO O-PHENETHYL ALDOXIMES

P T GALLAGHER
, A P LIGHTFOOT
, C J MOODY
, A M Z SLAWIN

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Addition of Grignard and organolithium reagents to O-phenethyl aldoximes in the presence of boron trifluoride etherate gives secondary hydroxylamines in 21-84% yield with 38-95% diastereomeric excess.

Original language	English
Pages (from-to)	445-446
Number of pages	2
Journal	Synlett
Issue number	5
Publication status	Published - May 1995

Keywords

ASYMMETRIC ADDITION
CHIRAL OXIME ETHER
HYDROXYLAMINE
ALDEHYDE-SAMP HYDRAZONES
ALPHA-IMINO ESTERS
OXIME ETHERS

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@article{1257b0af4b81419982116f7b73c41e70,

title = "ASYMMETRIC ADDITION OF ORGANOMETALLIC REAGENTS TO O-PHENETHYL ALDOXIMES",

abstract = "Addition of Grignard and organolithium reagents to O-phenethyl aldoximes in the presence of boron trifluoride etherate gives secondary hydroxylamines in 21-84\% yield with 38-95\% diastereomeric excess.",

keywords = "ASYMMETRIC ADDITION, CHIRAL OXIME ETHER, HYDROXYLAMINE, ALDEHYDE-SAMP HYDRAZONES, ALPHA-IMINO ESTERS, OXIME ETHERS",

author = "GALLAGHER, \{P T\} and LIGHTFOOT, \{A P\} and MOODY, \{C J\} and SLAWIN, \{A M Z\}",

year = "1995",

month = may,

language = "English",

pages = "445--446",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "5",

}

TY - JOUR

T1 - ASYMMETRIC ADDITION OF ORGANOMETALLIC REAGENTS TO O-PHENETHYL ALDOXIMES

AU - GALLAGHER, P T

AU - LIGHTFOOT, A P

AU - MOODY, C J

AU - SLAWIN, A M Z

PY - 1995/5

Y1 - 1995/5

N2 - Addition of Grignard and organolithium reagents to O-phenethyl aldoximes in the presence of boron trifluoride etherate gives secondary hydroxylamines in 21-84% yield with 38-95% diastereomeric excess.

AB - Addition of Grignard and organolithium reagents to O-phenethyl aldoximes in the presence of boron trifluoride etherate gives secondary hydroxylamines in 21-84% yield with 38-95% diastereomeric excess.

KW - ASYMMETRIC ADDITION

KW - CHIRAL OXIME ETHER

KW - HYDROXYLAMINE

KW - ALDEHYDE-SAMP HYDRAZONES

KW - ALPHA-IMINO ESTERS

KW - OXIME ETHERS

M3 - Comment/debate

SN - 0936-5214

SP - 445

EP - 446

JO - Synlett

JF - Synlett

IS - 5

ER -

ASYMMETRIC ADDITION OF ORGANOMETALLIC REAGENTS TO O-PHENETHYL ALDOXIMES

Abstract

Keywords

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