Assembly and export of MHC class I ligands

A Antoniou; Simon John Powis; T Elliott

doi:10.1016/S0952-7915(02)00010-9

Assembly and export of MHC class I ligands

Research output: Contribution to journal › Article › peer-review

Abstract

During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8(+) T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide-ligand binding.

Original language	English
Pages (from-to)	75-81
Number of pages	7
Journal	Current Opinion in Immunology
Volume	15
DOIs	https://doi.org/10.1016/S0952-7915(02)00010-9
Publication status	Published - Feb 2003

Keywords

COMPLEX CLASS-I
NEGATIVE CELL-LINE
ENDOPLASMIC-RETICULUM
QUALITY-CONTROL
HEAVY-CHAIN
MEMBRANE-PROTEINS
LOADING COMPLEX
ALPHA-2 DOMAIN
CALNEXIN
MOLECULES

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10.1016/S0952-7915(02)00010-9

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title = "Assembly and export of MHC class I ligands",

abstract = "During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8(+) T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide-ligand binding.",

keywords = "COMPLEX CLASS-I, NEGATIVE CELL-LINE, ENDOPLASMIC-RETICULUM, QUALITY-CONTROL, HEAVY-CHAIN, MEMBRANE-PROTEINS, LOADING COMPLEX, ALPHA-2 DOMAIN, CALNEXIN, MOLECULES",

author = "A Antoniou and Powis, \{Simon John\} and T Elliott",

year = "2003",

month = feb,

doi = "10.1016/S0952-7915(02)00010-9",

language = "English",

volume = "15",

pages = "75--81",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

publisher = "Elsevier",

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TY - JOUR

T1 - Assembly and export of MHC class I ligands

AU - Antoniou, A

AU - Powis, Simon John

AU - Elliott, T

PY - 2003/2

Y1 - 2003/2

N2 - During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8(+) T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide-ligand binding.

AB - During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8(+) T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide-ligand binding.

KW - COMPLEX CLASS-I

KW - NEGATIVE CELL-LINE

KW - ENDOPLASMIC-RETICULUM

KW - QUALITY-CONTROL

KW - HEAVY-CHAIN

KW - MEMBRANE-PROTEINS

KW - LOADING COMPLEX

KW - ALPHA-2 DOMAIN

KW - CALNEXIN

KW - MOLECULES

UR - https://www.scopus.com/pages/publications/0037290828

U2 - 10.1016/S0952-7915(02)00010-9

DO - 10.1016/S0952-7915(02)00010-9

M3 - Article

SN - 0952-7915

VL - 15

SP - 75

EP - 81

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -

Assembly and export of MHC class I ligands

Abstract

Keywords

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