Abstract
During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8(+) T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide-ligand binding.
Original language | English |
---|---|
Pages (from-to) | 75-81 |
Number of pages | 7 |
Journal | Current Opinion in Immunology |
Volume | 15 |
DOIs | |
Publication status | Published - Feb 2003 |
Keywords
- COMPLEX CLASS-I
- NEGATIVE CELL-LINE
- ENDOPLASMIC-RETICULUM
- QUALITY-CONTROL
- HEAVY-CHAIN
- MEMBRANE-PROTEINS
- LOADING COMPLEX
- ALPHA-2 DOMAIN
- CALNEXIN
- MOLECULES