Assembly and export of MHC class I ligands

A Antoniou, Simon John Powis, T Elliott

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8(+) T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide-ligand binding.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalCurrent Opinion in Immunology
Volume15
DOIs
Publication statusPublished - Feb 2003

Keywords

  • COMPLEX CLASS-I
  • NEGATIVE CELL-LINE
  • ENDOPLASMIC-RETICULUM
  • QUALITY-CONTROL
  • HEAVY-CHAIN
  • MEMBRANE-PROTEINS
  • LOADING COMPLEX
  • ALPHA-2 DOMAIN
  • CALNEXIN
  • MOLECULES

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