Aryl sulfones: a new class of gamma-secretase inhibitors

M  Teall; P  Oakley; T  Harrison; D  Shaw; E  Kay; J  Elliott; U  Gerhard; J L  Castro; M  Shearman; R G  Ball; N N  Tsou

doi:10.1016/j.bmcl.2004.12.017

Aryl sulfones: a new class of gamma-secretase inhibitors

M Teall, P Oakley, T Harrison, D Shaw, E Kay, J Elliott, U Gerhard, J L Castro, M Shearman, R G Ball, N N Tsou

Research output: Contribution to journal › Article › peer-review

Abstract

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. (c) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2685-2688
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2004.12.017
Publication status	Published - 16 May 2005

Keywords

ALZHEIMERS-DISEASE

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10.1016/j.bmcl.2004.12.017

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title = "Aryl sulfones: a new class of gamma-secretase inhibitors",

abstract = "The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. (c) 2004 Elsevier Ltd. All rights reserved.",

keywords = "ALZHEIMERS-DISEASE",

author = "M Teall and P Oakley and T Harrison and D Shaw and E Kay and J Elliott and U Gerhard and Castro, {J L} and M Shearman and Ball, {R G} and Tsou, {N N}",

year = "2005",

month = may,

day = "16",

doi = "10.1016/j.bmcl.2004.12.017",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Aryl sulfones: a new class of gamma-secretase inhibitors

AU - Teall, M

AU - Oakley, P

AU - Harrison, T

AU - Shaw, D

AU - Kay, E

AU - Elliott, J

AU - Gerhard, U

AU - Castro, J L

AU - Shearman, M

AU - Ball, R G

AU - Tsou, N N

PY - 2005/5/16

Y1 - 2005/5/16

N2 - The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. (c) 2004 Elsevier Ltd. All rights reserved.

AB - The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. (c) 2004 Elsevier Ltd. All rights reserved.

KW - ALZHEIMERS-DISEASE

U2 - 10.1016/j.bmcl.2004.12.017

DO - 10.1016/j.bmcl.2004.12.017

M3 - Article

VL - 15

SP - 2685

EP - 2688

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Aryl sulfones: a new class of gamma-secretase inhibitors

Abstract

Keywords

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