Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

Christopher P. A. T. Lawson; Alexandra M. Z. Slawin; Nicholas J. Westwood

doi:10.1039/c0cc03624b

Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

Christopher P. A. T. Lawson, Alexandra M. Z. Slawin, Nicholas J. Westwood

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Abstract

A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.

Original language	English
Pages (from-to)	1057-1059
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	3
DOIs	https://doi.org/10.1039/c0cc03624b
Publication status	Published - 2011

Keywords

SMALL-MOLECULE TOOL
ARYL HALIDES
BOND FORMATION
C-N
COUPLING REACTIONS
VINYL HALIDES
MYOSIN-II
HETEROCYCLES
GUANIDINES
INHIBITOR

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title = "Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin",

abstract = "A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.",

keywords = "SMALL-MOLECULE TOOL, ARYL HALIDES, BOND FORMATION, C-N, COUPLING REACTIONS, VINYL HALIDES, MYOSIN-II, HETEROCYCLES, GUANIDINES, INHIBITOR",

author = "Lawson, \{Christopher P. A. T.\} and Slawin, \{Alexandra M. Z.\} and Westwood, \{Nicholas J.\}",

year = "2011",

doi = "10.1039/c0cc03624b",

language = "English",

volume = "47",

pages = "1057--1059",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "3",

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TY - JOUR

T1 - Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

AU - Lawson, Christopher P. A. T.

AU - Slawin, Alexandra M. Z.

AU - Westwood, Nicholas J.

PY - 2011

Y1 - 2011

N2 - A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.

AB - A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.

KW - SMALL-MOLECULE TOOL

KW - ARYL HALIDES

KW - BOND FORMATION

KW - C-N

KW - COUPLING REACTIONS

KW - VINYL HALIDES

KW - MYOSIN-II

KW - HETEROCYCLES

KW - GUANIDINES

KW - INHIBITOR

UR - https://www.scopus.com/pages/publications/78650466634

U2 - 10.1039/c0cc03624b

DO - 10.1039/c0cc03624b

M3 - Article

SN - 1359-7345

VL - 47

SP - 1057

EP - 1059

JO - Chemical Communications

JF - Chemical Communications

IS - 3

ER -

Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

Abstract

Keywords

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