Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

Christopher P. A. T. Lawson, Alexandra M. Z. Slawin, Nicholas J. Westwood

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.

Original languageEnglish
Pages (from-to)1057-1059
Number of pages3
JournalChemical Communications
Volume47
Issue number3
DOIs
Publication statusPublished - 2011

Keywords

  • SMALL-MOLECULE TOOL
  • ARYL HALIDES
  • BOND FORMATION
  • C-N
  • COUPLING REACTIONS
  • VINYL HALIDES
  • MYOSIN-II
  • HETEROCYCLES
  • GUANIDINES
  • INHIBITOR

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