Application of chemically induced dynamic nuclear polarization to the nitration of N-acetyltyrosine and to some reactions of peroxynitrite

A R Butler, T J Rutherford, D M Short, J H Ridd

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

By the observation of chemically induced dynamic nuclear polarization in N-15 NMR spectroscopy it has been shown that nitration of N-acetyltyrosine, even render acidic conditions, is largely a radical process. In the alkaline reaction of tyrosine with peroxynitrite the main products are nitrite and nitrate, both produced by a radical pathway, and tyrosine nitration is a minor reaction. It is suggested that tyrosine catalyzes the production of NOS and HO. from peroxgnitrite. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)472-482
Number of pages11
JournalNitric Oxide
Volume4
Issue number5
DOIs
Publication statusPublished - Oct 2000

Keywords

  • nitric oxide
  • peroxynitrite
  • N-15 NMR
  • nuclear polarization
  • radicals
  • NITRIC-OXIDE
  • SUPEROXIDE-DISMUTASE
  • TYROSINE NITRATION
  • N-15 CIDNP
  • ACID
  • DECOMPOSITION
  • MECHANISMS
  • CHEMISTRY
  • ADDUCT

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