Apoptosis and DNA methylation

Huan X Meng; James A Hackett; Colm Nestor; Donncha S Dunican; Monika Madej; James P Reddington; Sari Pennings; David J Harrison; Richard R Meehan

doi:10.3390/cancers3021798

Apoptosis and DNA methylation

Huan X Meng, James A Hackett, Colm Nestor, Donncha S Dunican, Monika Madej, James P Reddington, Sari Pennings, David J Harrison, Richard R Meehan

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.

Original language	English
Pages (from-to)	1798-1820
Number of pages	23
Journal	Cancers
Volume	3
Issue number	2
DOIs	https://doi.org/10.3390/cancers3021798
Publication status	Published - 1 Apr 2011

Keywords

Epigenetics
Dnmt1
Apoptosis
Mbd4
TDG
Demethylation
5-hydroxymethylation
DNA repair

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers3021798

meng2011cancers1798
© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
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AU - Meng, Huan X

AU - Hackett, James A

AU - Nestor, Colm

AU - Dunican, Donncha S

AU - Madej, Monika

AU - Reddington, James P

AU - Pennings, Sari

AU - Harrison, David J

AU - Meehan, Richard R

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AB - Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.

KW - Epigenetics

KW - Dnmt1

KW - Apoptosis

KW - Mbd4

KW - TDG

KW - Demethylation

KW - 5-hydroxymethylation

KW - DNA repair

UR - http://www.mdpi.com/2072-6694/3/2/1798

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VL - 3

SP - 1798

EP - 1820

JO - Cancers

JF - Cancers

IS - 2

ER -

Apoptosis and DNA methylation

Abstract

Keywords

UN SDGs

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