Antiviral agents added to corticosteroids for early treatment of adults with acute idiopathic facial nerve paralysis (Bell Palsy)

Frank Sullivan; Fergus Daly; Ildiko Gagyor

doi:10.1001/jama.2016.10160

Antiviral agents added to corticosteroids for early treatment of adults with acute idiopathic facial nerve paralysis (Bell Palsy)

Frank Sullivan, Fergus Daly, Ildiko Gagyor

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

CLINICAL QUESTION: Compared with oral corticosteroids alone, are oral antiviral drugs associated with improved outcomes when combined with oral corticosteroids in patients presenting within 72 hours of the onset of Bell palsy?

BOTTOM LINE: Compared with oral corticosteroids alone, the addition of acyclovir, valacyclovir, or famcyclovir to oral corticosteroids for treatment of Bell palsy was associated with a higher proportion of people who recovered at 3- to 12-month follow-up. The quality of evidence is limited by heterogeneity, imprecision of the result estimates, and risk of bias.

Original language	English
Pages (from-to)	874-5
Number of pages	2
Journal	JAMA - Journal of the American Medical Association
Volume	316
Issue number	8
DOIs	https://doi.org/10.1001/jama.2016.10160
Publication status	Published - 23 Aug 2016

Keywords

Adrenal Cortex Hormones
Adult
Antiviral Agents
Bell Palsy
Drug Therapy, Combination
Facial Nerve
Facial Paralysis
Humans
Comment
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1001/jama.2016.10160

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title = "Antiviral agents added to corticosteroids for early treatment of adults with acute idiopathic facial nerve paralysis (Bell Palsy)",

abstract = "CLINICAL QUESTION: Compared with oral corticosteroids alone, are oral antiviral drugs associated with improved outcomes when combined with oral corticosteroids in patients presenting within 72 hours of the onset of Bell palsy?BOTTOM LINE: Compared with oral corticosteroids alone, the addition of acyclovir, valacyclovir, or famcyclovir to oral corticosteroids for treatment of Bell palsy was associated with a higher proportion of people who recovered at 3- to 12-month follow-up. The quality of evidence is limited by heterogeneity, imprecision of the result estimates, and risk of bias.",

keywords = "Adrenal Cortex Hormones, Adult, Antiviral Agents, Bell Palsy, Drug Therapy, Combination, Facial Nerve, Facial Paralysis, Humans, Comment, Journal Article",

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AU - Sullivan, Frank

AU - Daly, Fergus

AU - Gagyor, Ildiko

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N2 - CLINICAL QUESTION: Compared with oral corticosteroids alone, are oral antiviral drugs associated with improved outcomes when combined with oral corticosteroids in patients presenting within 72 hours of the onset of Bell palsy?BOTTOM LINE: Compared with oral corticosteroids alone, the addition of acyclovir, valacyclovir, or famcyclovir to oral corticosteroids for treatment of Bell palsy was associated with a higher proportion of people who recovered at 3- to 12-month follow-up. The quality of evidence is limited by heterogeneity, imprecision of the result estimates, and risk of bias.

AB - CLINICAL QUESTION: Compared with oral corticosteroids alone, are oral antiviral drugs associated with improved outcomes when combined with oral corticosteroids in patients presenting within 72 hours of the onset of Bell palsy?BOTTOM LINE: Compared with oral corticosteroids alone, the addition of acyclovir, valacyclovir, or famcyclovir to oral corticosteroids for treatment of Bell palsy was associated with a higher proportion of people who recovered at 3- to 12-month follow-up. The quality of evidence is limited by heterogeneity, imprecision of the result estimates, and risk of bias.

KW - Adrenal Cortex Hormones

KW - Adult

KW - Antiviral Agents

KW - Bell Palsy

KW - Drug Therapy, Combination

KW - Facial Nerve

KW - Facial Paralysis

KW - Humans

KW - Comment

KW - Journal Article

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JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

IS - 8

ER -

Antiviral agents added to corticosteroids for early treatment of adults with acute idiopathic facial nerve paralysis (Bell Palsy)

Abstract

Keywords

UN SDGs

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