Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis

Michael Winn; Rebecca J. M. Goss; Ken-ichi Kimura; Timothy D. H. Bugg

doi:10.1039/b816215h

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis

Michael Winn, Rebecca J. M. Goss, Ken-ichi Kimura, Timothy D. H. Bugg^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.

Original language	English
Pages (from-to)	279-304
Number of pages	26
Journal	Natural Product Reports
Volume	27
Issue number	2
DOIs	https://doi.org/10.1039/b816215h
Publication status	Published - 2010

Keywords

PEPTIDE-BOND FORMATION
PRECURSOR-DIRECTED BIOSYNTHESIS
SPHEROPLAST FORMING ACTIVITY
ACETYLMURAMYL-PENTAPEPTIDE-TRANSLOCASE
STREPTOMYCES-TENDAE TU901
PSEUDOMONAS-AERUGINOSA ACTIVITY
BACTERIAL PEPTIDOGLYCAN SYNTHESIS
1ST MEMBRANE STEP
MUREIDOMYCINS-A-D
LYSIS PROTEIN-E

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title = "Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis",

abstract = "The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.",

keywords = "PEPTIDE-BOND FORMATION, PRECURSOR-DIRECTED BIOSYNTHESIS, SPHEROPLAST FORMING ACTIVITY, ACETYLMURAMYL-PENTAPEPTIDE-TRANSLOCASE, STREPTOMYCES-TENDAE TU901, PSEUDOMONAS-AERUGINOSA ACTIVITY, BACTERIAL PEPTIDOGLYCAN SYNTHESIS, 1ST MEMBRANE STEP, MUREIDOMYCINS-A-D, LYSIS PROTEIN-E",

author = "Michael Winn and Goss, {Rebecca J. M.} and Ken-ichi Kimura and Bugg, {Timothy D. H.}",

year = "2010",

doi = "10.1039/b816215h",

language = "English",

volume = "27",

pages = "279--304",

journal = "Natural Product Reports",

issn = "0265-0568",

publisher = "Royal Society of Chemistry",

number = "2",

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TY - JOUR

T1 - Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis

AU - Winn, Michael

AU - Goss, Rebecca J. M.

AU - Kimura, Ken-ichi

AU - Bugg, Timothy D. H.

PY - 2010

Y1 - 2010

N2 - The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.

AB - The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.

KW - PEPTIDE-BOND FORMATION

KW - PRECURSOR-DIRECTED BIOSYNTHESIS

KW - SPHEROPLAST FORMING ACTIVITY

KW - ACETYLMURAMYL-PENTAPEPTIDE-TRANSLOCASE

KW - STREPTOMYCES-TENDAE TU901

KW - PSEUDOMONAS-AERUGINOSA ACTIVITY

KW - BACTERIAL PEPTIDOGLYCAN SYNTHESIS

KW - 1ST MEMBRANE STEP

KW - MUREIDOMYCINS-A-D

KW - LYSIS PROTEIN-E

U2 - 10.1039/b816215h

DO - 10.1039/b816215h

M3 - Review article

SN - 0265-0568

VL - 27

SP - 279

EP - 304

JO - Natural Product Reports

JF - Natural Product Reports

IS - 2

ER -

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis

Abstract

Keywords

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