Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis

Michael Winn, Rebecca J. M. Goss, Ken-ichi Kimura, Timothy D. H. Bugg*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

208 Citations (Scopus)

Abstract

The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.

Original languageEnglish
Pages (from-to)279-304
Number of pages26
JournalNatural Product Reports
Volume27
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • PEPTIDE-BOND FORMATION
  • PRECURSOR-DIRECTED BIOSYNTHESIS
  • SPHEROPLAST FORMING ACTIVITY
  • ACETYLMURAMYL-PENTAPEPTIDE-TRANSLOCASE
  • STREPTOMYCES-TENDAE TU901
  • PSEUDOMONAS-AERUGINOSA ACTIVITY
  • BACTERIAL PEPTIDOGLYCAN SYNTHESIS
  • 1ST MEMBRANE STEP
  • MUREIDOMYCINS-A-D
  • LYSIS PROTEIN-E

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