Abstract
The nature of anticipatory responding in rats with unilateral subthalamic nucleus lesions was examined. Rats were trained to respond toward visual targets that were preceded by 1 of 4 different cues. For normal rats, a cue invokes an involuntary attentional orienting that enhances processing of the target at the location of attention. The cue is also a salient stimulus to which a response must be suppressed. Therefore, this task was used to investigate possible attentional impairments, as well as the ability of a lesioned rat to suppress competing motor programs. Responding under target control was not affected by the lesion. Then was an increase in anticipatory responses before target onset, which could be accounted for by a failure to inhibit contralateral responses.
Original language | English |
---|---|
Pages (from-to) | 150-157 |
Number of pages | 8 |
Journal | Behavioral Neuroscience |
Volume | 114 |
DOIs | |
Publication status | Published - Feb 2000 |
Keywords
- STRIATAL DOPAMINE DEPLETION
- BASAL GANGLIA
- PARKINSONS-DISEASE
- REACTION-TIME
- ATTENTION
- CIRCUITS
- DEFICITS
- INDUCE
- MODELS