Antibodies against the paramyxovirus SV5 in the cerebrospinal fluids of some multiple sclerosis patients

K. K.A. Goswami, R. E. Randall, L. S. Lange, W. C. Russell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Multiple sclerosis is a demyelinating disease of the central nervous system and although there is little doubt that an infectious agent (or agents) is involved (for reviews see refs 1 and 2) it has not been possible to demonstrate this unequivocally by any direct relationship to a given agent (see, for example refs 3-5). Here we show that a significant proportion of patients with multiple sclerosis have antibodies against the paramyxovirus SV5 (simian virus 5) in their cerebrospinal fluid and in some of these such antibodies form a major proportion of the total immunoglobulin content. Further, we have been able to demonstrate that the oligo-clonal bands displayed on electrophoresis of the cerebrospinal fluid of these patients can be removed by prior absorption with SV5 virus antigen.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalNature
Volume327
Issue number6119
DOIs
Publication statusPublished - 1 Jan 1987

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