Angiotensin and angiotensin receptors in cartilaginous fishes: a review

WG Anderson, MC Cerra, A Wells, ML Tierney, B Tota, Y Takei, Neil Hazon

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

In mammals, a principal bioactive component of the renin-angiotensin system (RAS), angiotensin II (ANG II), is known to be vasopressor, dipsogenic, a stimulant of adrenocortical secretion and to control glomerular and renal tubular function. Historically, a RAS analogous to that found in mammals was thought to have first evolved in the bony fishes. Recent research has identified the unusually structured elasmobranch [Asp(1)-Pro(3)-Ile(5)] ANG II. Physiological studies have demonstrated that ANG II in elasmobranchs is vasopressor, and stimulates interrenal gland production of the elasmobranch corticosteroid 1 alpha -hydroxycorticosterone. The specific binding of ANG II in elasmobranchs has been reported in gills, heart, interrenal gland, gut and rectal gland. The precise osmoregulatory role ANG II plays in cartilaginous fishes is not yet known; however, putative evidence is emerging for a role in the control of drinking rate, rectal gland secretion, and kidney function. (C) 2001 Elsevier Science Inc. All rights reserved.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalComparative Biochemistry and Physiology
Volume128
Publication statusPublished - Jan 2001

Keywords

  • angiotensin
  • receptors
  • osmoregulation
  • elasmobranch
  • cardiovascular
  • kidney
  • rectal gland
  • drinking
  • CONVERTING-ENZYME-INHIBITOR
  • ELASMOBRANCH RECTAL GLAND
  • SCYLIORHINUS-CANICULA
  • SECRETORY DYNAMICS
  • SQUALUS-ACANTHIAS
  • II RECEPTORS
  • DOGFISH
  • 1-ALPHA-HYDROXYCORTICOSTERONE
  • RENIN
  • SYSTEM

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