An investigation of mitochondrial haplogroups in autism

Lindsey Kent, L Gallagher, HR Elliot, C Mowbray, PF Chinnery

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Family and twin studies provide strong evidence of a major genetic influence in autism, but the underlying gene defects have yet to be characterized. The mothers of boys with autism share autistic traits, raising the possibility of a maternally inherited factor. Mitochondrial DNA (mtDNA) is almost exclusively inherited down the maternal line. We therefore explored the possibility that a particular mtDNA lineage contributes to the risk of developing autism. The mtDNA haplogroup was determined in 162 autism probands, and compared to two sets of population controls. Results show no compelling evidence of an association of any mitochondrial haplogroup in autism. (c) 2007 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)987-989
Number of pages3
JournalAmerican Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Volume147B
Issue number6
Early online date27 Dec 2007
DOIs
Publication statusPublished - 5 Sept 2008

Keywords

  • child psychiatry
  • molecular genetics
  • autism spectrum disorders
  • CARRIER SLC25A12 GENE
  • SPECTRUM DISORDERS
  • DNA HAPLOGROUPS
  • CHILDREN
  • POLYMORPHISMS
  • ASSOCIATION
  • PHENOTYPE
  • PARENTS
  • DISEASE

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