Projects per year
Abstract
The population of non-growing follicles present in the ovary is defined as the ovarian reserve. This underpins the reproductive lifespan in women, with its depletion determining age at loss of fertility and the menopause. Data amassed from published results of indirect invasive and non-invasive procedures has resulted in the generation of predictive models which estimate the ovarian reserve from conception throughout adult life. The distribution of follicles in the ovary is not uniform, with the great majority of NGFs located in the cortex, which is the region normally biopsied and used for fertility preservation. Previous models have however analysed whole ovary NGF populations and ovarian volumes, but not cortical NGF density. In this study we compared mean non-growing follicle density values obtained from tissue samples from 13 ovarian cortical biopsies (16-37 years) against age- matched model-predicted values generated from population and ovarian volume models, taking into account the proportion of the ovary that is cortex. A mean non-growing follicle density was calculated for each patient by counting all follicles in a given volume of freshly biopsied ovarian cortical tissue. These values were compared to age-matched model generated densities and the correlation between data sets tested. Non-growing follicle density values obtained from fresh biopsied ovarian cortex samples closely matched model generated data with low mean difference, tight agreement limits and no proportional error between the observed and predicted results. These findings validate the use of the population and ovarian volume models to accurately predict mean follicle density in the ovarian cortex of adult women.
Original language | English |
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Pages (from-to) | 1089-1095 |
Number of pages | 7 |
Journal | Journal of Assisted Reproduction and Genetics |
Volume | 32 |
Issue number | 7 |
Early online date | 5 Jun 2015 |
DOIs | |
Publication status | Published - Jul 2015 |
Keywords
- Adolescent
- Adult
- Aging
- Female
- Humans
- Models, Biological
- Ovarian Follicle
- Ovary
- Reproducibility of Results
- Young Adult
- Journal Article
- Research Support, Non-U.S. Gov't
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Dive into the research topics of 'An externally validated age-related model of mean follicle density in the cortex of the human ovary'. Together they form a unique fingerprint.Projects
- 3 Finished
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Impact Acceleration Account: Impact Acceleration Account
Woollins, J. D. (PI)
1/10/15 → 31/03/17
Project: Standard
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Medical and Healthcare mobile apps: Medical and healthcare mobile apps based on St Andrews research
Kelsey, T. (PI)
1/01/15 → 31/08/15
Project: Standard
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A Constraint Solver Synthesiser: A Constraint Solver Synthesiser
Miguel, I. J. (PI), Balasubramaniam, D. (CoI), Gent, I. P. (CoI), Kelsey, T. (CoI) & Linton, S. A. (CoI)
1/10/09 → 30/09/14
Project: Standard
Datasets
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Data underpinning - An externally validated age-related model of mean follicle density in the cortex of the human ovary
McLaughlin, M. (Creator), Kelsey, T. W. (Creator), Wallace, W. H. B. (Creator), Anderson, R. A. (Creator) & Telfer, E. E. (Creator), University of St Andrews, 2015
DOI: 10.17630/e2063cc8-68a9-4006-a2e2-197a73a6c286
Dataset
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