An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals

Sunil V. Sharma*, Cristina Pubill-Ulldemolins*, Enrico Marelli, Rebecca J. M. Goss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

The development of mild, aqueous conditions for the cross-coupling of highly functionalized (hetero)aryl chlorides or bromides is attractive, enabling their functionalization and diversification. Herein, we report a general method for Suzuki–Miyaura cross-coupling at 37 °C in aqueous media in the presence of air. We demonstrate application of this general methodology for derivatisation of (poly)chlorinated, medicinally active compounds and halogenated amino acids. The approach holds the potential to be a useful tool for late-stage functionalization or analogue generation.
Original languageEnglish
Pages (from-to)5722-5727
JournalOrganic Chemistry Frontiers
Volume8
Issue number20
Early online date19 Aug 2021
DOIs
Publication statusPublished - 21 Oct 2021

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