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Abstract
The development of mild, aqueous conditions for the cross-coupling of highly functionalized (hetero)aryl chlorides or bromides is attractive, enabling their functionalization and diversification. Herein, we report a general method for Suzuki–Miyaura cross-coupling at 37 °C in aqueous media in the presence of air. We demonstrate application of this general methodology for derivatisation of (poly)chlorinated, medicinally active compounds and halogenated amino acids. The approach holds the potential to be a useful tool for late-stage functionalization or analogue generation.
Original language | English |
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Pages (from-to) | 5722-5727 |
Journal | Organic Chemistry Frontiers |
Volume | 8 |
Issue number | 20 |
Early online date | 19 Aug 2021 |
DOIs | |
Publication status | Published - 21 Oct 2021 |
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Dive into the research topics of 'An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals'. Together they form a unique fingerprint.Projects
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