An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

AR Butler; RA Field; IR Greig; Frederick Werner Flitney; SK Bisland; F Khan; JJ Belch

doi:10.1006/niox.1997.0125

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

AR Butler, RA Field, IR Greig, Frederick Werner Flitney, SK Bisland, F Khan, JJ Belch

School of Biology

Research output: Contribution to journal › Article › peer-review

Abstract

A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	Nitric Oxide
Volume	1
Issue number	3
DOIs	https://doi.org/10.1006/niox.1997.0125
Publication status	Published - Jun 1997

Keywords

NITRIC-OXIDE
S-NITROSOTHIOLS
INHIBITION

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10.1006/niox.1997.0125

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abstract = "A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.",

keywords = "NITRIC-OXIDE, S-NITROSOTHIOLS, INHIBITION",

author = "AR Butler and RA Field and IR Greig and Flitney, {Frederick Werner} and SK Bisland and F Khan and JJ Belch",

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AU - Butler, AR

AU - Field, RA

AU - Greig, IR

AU - Flitney, Frederick Werner

AU - Bisland, SK

AU - Khan, F

AU - Belch, JJ

PY - 1997/6

Y1 - 1997/6

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AB - A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

KW - NITRIC-OXIDE

KW - S-NITROSOTHIOLS

KW - INHIBITION

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JO - Nitric Oxide

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ER -

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

Abstract

Keywords

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