An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

AR Butler, RA Field, IR Greig, Frederick Werner Flitney, SK Bisland, F Khan, JJ Belch

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalNitric Oxide
Volume1
Issue number3
DOIs
Publication statusPublished - Jun 1997

Keywords

  • NITRIC-OXIDE
  • S-NITROSOTHIOLS
  • INHIBITION

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