An enzymatic route to selenazolines

Jesko Koehnke, Falk Morawitz, Andrew F. Bent, Wael E. Houssen, Sally L. Shirran, Matthew A. Fuszard, Iain A. Smellie, Catherine H. Botting, Margaret C. M. Smith, Marcel Jaspars*, James H. Naismith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)
3 Downloads (Pure)


Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.

Original languageEnglish
Pages (from-to)564-567
Number of pages4
Issue number5
Publication statusPublished - 18 Mar 2013


  • Patellamides
  • Macrocyclization
  • Derivatives
  • Biochemistry
  • Line
  • Biosynthesis
  • Selenazolines


Dive into the research topics of 'An enzymatic route to selenazolines'. Together they form a unique fingerprint.

Cite this