An enzymatic route to selenazolines

Jesko Koehnke, Falk Morawitz, Andrew F. Bent, Wael E. Houssen, Sally L. Shirran, Matthew A. Fuszard, Iain A. Smellie, Catherine H. Botting, Margaret C. M. Smith, Marcel Jaspars*, James H. Naismith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)
3 Downloads (Pure)

Abstract

Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.

Original languageEnglish
Pages (from-to)564-567
Number of pages4
JournalChemBioChem
Volume14
Issue number5
DOIs
Publication statusPublished - 18 Mar 2013

Keywords

  • Patellamides
  • Macrocyclization
  • Derivatives
  • Biochemistry
  • Line
  • Biosynthesis
  • Selenazolines

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