An enzymatic route to 5-deoxy-5-[F-18]fluoro-D-ribose, a [F-18]-fluorinated sugar for PET imaging

Mayca Onega; Juozas Domarkas; Hai Deng; Lutz F. Schweiger; Timothy A. D. Smith; Andrew E. Welch; Christophe Plisson; Antony D. Gee; David O'Hagan

doi:10.1039/b919364b

An enzymatic route to 5-deoxy-5-[F-18]fluoro-D-ribose, a [F-18]-fluorinated sugar for PET imaging

Mayca Onega
, Juozas Domarkas
, Hai Deng
, Lutz F. Schweiger
, Timothy A. D. Smith
, Andrew E. Welch
, Christophe Plisson
, Antony D. Gee
, David O'Hagan

Research output: Contribution to journal › Article › peer-review

Abstract

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.

Original language	English
Pages (from-to)	139-141
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	1
Early online date	10 Nov 2009
DOIs	https://doi.org/10.1039/b919364b
Publication status	Published - 7 Jan 2010

Keywords

NUCLEOSIDE HYDROLASE
STREPTOMYCES-CATTLEYA
TRYPANOSOMA-VIVAX
BOND FORMATION
L-TRYPTOPHAN
T. VIVAX
CHEMISTRY
MECHANISM
COMPLEX
PURINE

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10.1039/b919364b

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title = "An enzymatic route to 5-deoxy-5-[F-18]fluoro-D-ribose, a [F-18]-fluorinated sugar for PET imaging",

abstract = "An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.",

keywords = "NUCLEOSIDE HYDROLASE, STREPTOMYCES-CATTLEYA, TRYPANOSOMA-VIVAX, BOND FORMATION, L-TRYPTOPHAN, T. VIVAX, CHEMISTRY, MECHANISM, COMPLEX, PURINE",

author = "Mayca Onega and Juozas Domarkas and Hai Deng and Schweiger, \{Lutz F.\} and Smith, \{Timothy A. D.\} and Welch, \{Andrew E.\} and Christophe Plisson and Gee, \{Antony D.\} and David O'Hagan",

year = "2010",

month = jan,

day = "7",

doi = "10.1039/b919364b",

language = "English",

volume = "46",

pages = "139--141",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - An enzymatic route to 5-deoxy-5-[F-18]fluoro-D-ribose, a [F-18]-fluorinated sugar for PET imaging

AU - Onega, Mayca

AU - Domarkas, Juozas

AU - Deng, Hai

AU - Schweiger, Lutz F.

AU - Smith, Timothy A. D.

AU - Welch, Andrew E.

AU - Plisson, Christophe

AU - Gee, Antony D.

AU - O'Hagan, David

PY - 2010/1/7

Y1 - 2010/1/7

N2 - An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.

AB - An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.

KW - NUCLEOSIDE HYDROLASE

KW - STREPTOMYCES-CATTLEYA

KW - TRYPANOSOMA-VIVAX

KW - BOND FORMATION

KW - L-TRYPTOPHAN

KW - T. VIVAX

KW - CHEMISTRY

KW - MECHANISM

KW - COMPLEX

KW - PURINE

UR - https://www.scopus.com/pages/publications/72149096554

U2 - 10.1039/b919364b

DO - 10.1039/b919364b

M3 - Article

SN - 1359-7345

VL - 46

SP - 139

EP - 141

JO - Chemical Communications

JF - Chemical Communications

IS - 1

ER -

An enzymatic route to 5-deoxy-5-[F-18]fluoro-D-ribose, a [F-18]-fluorinated sugar for PET imaging

Abstract

Keywords

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Enzymatic fluorination in Streptomyces: Enzymatic Fluorination in Streptomyces cattleya. Setting a framework for biotechnological development

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An enzymatic route to 5-deoxy-5-[F-18]fluoro-D-ribose, a [F-18]-fluorinated sugar for PET imaging

Abstract

Keywords

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Enzymatic fluorination in Streptomyces: Enzymatic Fluorination in Streptomyces cattleya. Setting a framework for biotechnological development

Cite this