An enzymatic route to 5-deoxy-5-[F-18]fluoro-D-ribose, a [F-18]-fluorinated sugar for PET imaging

Mayca Onega, Juozas Domarkas, Hai Deng, Lutz F. Schweiger, Timothy A. D. Smith, Andrew E. Welch, Christophe Plisson, Antony D. Gee, David O'Hagan

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalChemical Communications
Volume46
Issue number1
Early online date10 Nov 2009
DOIs
Publication statusPublished - 7 Jan 2010

Keywords

  • NUCLEOSIDE HYDROLASE
  • STREPTOMYCES-CATTLEYA
  • TRYPANOSOMA-VIVAX
  • BOND FORMATION
  • L-TRYPTOPHAN
  • T. VIVAX
  • CHEMISTRY
  • MECHANISM
  • COMPLEX
  • PURINE

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