An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

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Abstract

The fluorinase enzyme from Streptomyces cattleya is shown to catalyse a direct displacement of bromide and iodide by fluoride ion from 5′-bromodeoxyadenosine (5′-BrDA) and 5′-iododeoxyadenosine (5′-IDA) respectively to form 5′-fluorodeoxyadenosine (5′-FDA) in the absence of L-methionine (L-Met) or S-adenosyl-L-methionine (SAM). 5′-BrDA is the most efficient substrate for this enzyme catalysed Finkelstein reaction.
Original languageEnglish
Pages (from-to)7493-7496
Number of pages4
JournalOrganic & Biomolecular Chemistry
Volume17
Issue number32
Early online date25 Jul 2019
DOIs
Publication statusPublished - 28 Aug 2019

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