Aminergic modulation of glycine release in a spinal network controlling swimming in Xenopus laevis

Keith Thomas Sillar, J McDearmid, JF Scrymgeour-Wedderburn

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

1. Neuromodulators can effect changes in neural network function by strengthening or weakening synapses between neurons via presynaptic control of transmitter release. We have examined the effects of two biogenic amines on inhibitory connections of a spinal rhythm generator in Xenopus tadpoles.

2. Glycinergic inhibitory potentials occurring mid-cycle in motoneurons during swimming activity are reduced by 5-hydroxytryptamine (5-HT; serotonin) and enhanced by noradrenaline (NA). These opposing effects on inhibitory synaptic strength are mediated presynaptically where 5-HT decreases and Nrl increases the probability of glycine release from inhibitory terminals.

3. The amines also have contrasting effects on swimming: 5-HT increased motor burst durations while NA reduced swimming frequency Aminergic modulation of glycinergic transmission mag thus control fundamental parameters of swimming and force the spinal network to generate opposite extremes of its spectrum of possible outputs.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalThe Journal of Physiology
Volume503
Issue number1
Publication statusPublished - 15 Aug 1997

Keywords

  • POSTEMBRYONIC DEVELOPMENT
  • PATTERN GENERATOR
  • LAMPREY
  • CORD
  • 5-HYDROXYTRYPTAMINE
  • LOCOMOTION
  • NEURONS
  • INTERNEURONS
  • RHYTHMICITY
  • INHIBITION

Fingerprint

Dive into the research topics of 'Aminergic modulation of glycine release in a spinal network controlling swimming in Xenopus laevis'. Together they form a unique fingerprint.

Cite this