TY - JOUR
T1 - Ambulatory photodynamic therapy: a new concept in delivering photodynamic therapy
AU - Moseley, H
AU - Allen, John Walter
AU - Ibbotson, S
AU - Lesar, A
AU - McNeill, A
AU - Camacho-Lopez, M A
AU - Samuel, Ifor David William
AU - Ferguson, J
AU - Sibbett, Wilson
N1 - This exploitation of spectrally-selected and efficient commercial light emitting devices is the outcome of a joint idea shared between Professor John Allen and myself. This is an example of translating optical physics into clinical practice.
PY - 2006/4
Y1 - 2006/4
N2 - Background Photodynamic therapy (PDT) has been shown to be effective in treating Bowen's disease, superficial basal cell carcinoma and actinic keratosis.Objectives To investigate the feasibility of delivering PDT using a portable light-emitting diode device.Methods A prototype diode array, comprising 37 AlGaInP diodes cast in epoxy with a diffuser, and driven by a battery pack, was designed and constructed. A pilot study was carried out in five patients with histologically proven Bowen's disease who were referred for PDT with 5-aminolaevulinic acid. They were all treated in the hospital-based dermatology PDT suite such that each received the same level of supervision as patients receiving PDT with nonambulatory light sources. Patients recorded pain levels. In accordance with our usual practice, patients received two treatments at a 4-week interval.Results Four of five patients were clear at follow-up (range 6-13 months, median 9). Pain was classified as none or mild in 80% of treatments and moderate in the remainder.Conclusions There are many potential benefits of ambulatory PDT, including the possibility of a much higher patient throughput, and allowing effective treatment at home. This pilot study provides early promising data of the safety and efficacy of this approach.
AB - Background Photodynamic therapy (PDT) has been shown to be effective in treating Bowen's disease, superficial basal cell carcinoma and actinic keratosis.Objectives To investigate the feasibility of delivering PDT using a portable light-emitting diode device.Methods A prototype diode array, comprising 37 AlGaInP diodes cast in epoxy with a diffuser, and driven by a battery pack, was designed and constructed. A pilot study was carried out in five patients with histologically proven Bowen's disease who were referred for PDT with 5-aminolaevulinic acid. They were all treated in the hospital-based dermatology PDT suite such that each received the same level of supervision as patients receiving PDT with nonambulatory light sources. Patients recorded pain levels. In accordance with our usual practice, patients received two treatments at a 4-week interval.Results Four of five patients were clear at follow-up (range 6-13 months, median 9). Pain was classified as none or mild in 80% of treatments and moderate in the remainder.Conclusions There are many potential benefits of ambulatory PDT, including the possibility of a much higher patient throughput, and allowing effective treatment at home. This pilot study provides early promising data of the safety and efficacy of this approach.
KW - 5-aminolaevulinic acid
KW - Bowen's disease
KW - light-emitting diode
KW - photodynamic therapy
KW - 5-AMINOLEVULINIC ACID
KW - LIGHT-SOURCES
KW - PROTOPORPHYRIN-IX
KW - FLUENCE
KW - LASER
UR - http://www.scopus.com/inward/record.url?scp=33644870609&partnerID=8YFLogxK
UR - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2133.2006.07145.x
U2 - 10.1111/j.1365-2133.2006.07145.x
DO - 10.1111/j.1365-2133.2006.07145.x
M3 - Article
SN - 0007-0963
VL - 154
SP - 747
EP - 750
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 4
ER -