Alzheimer's disease in humans and other animals: a consequence of postreproductive life span and longevity rather than aging

Danielle Gunn-Moore; Oksana Kaidanovich-Beilin; Maria Carolina Gallego Iradi; Frank Gunn-Moore; Simon Lovestone

doi:10.1016/j.jalz.2017.08.014

Alzheimer's disease in humans and other animals: a consequence of postreproductive life span and longevity rather than aging

Danielle Gunn-Moore, Oksana Kaidanovich-Beilin, Maria Carolina Gallego Iradi, Frank Gunn-Moore, Simon Lovestone

Research output: Contribution to journal › Article › peer-review

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Abstract

Introduction Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes.

Methods We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease.

Results and Conclusions We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease.

Original language	English
Pages (from-to)	195-204
Journal	Alzheimer's and Dementia
Volume	14
Issue number	2
Early online date	30 Sept 2017
DOIs	https://doi.org/10.1016/j.jalz.2017.08.014
Publication status	Published - Feb 2018

Keywords

Longevity
Insulin signaling
Alzheimer's pathology
Animal models
Tau
Amyloid
GSK-3

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jalz.2017.08.014

AD-Diabetes-longevity_AAM
© 2017, The Alzheimer's Association. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.jalz.2017.08.014
Accepted author manuscript, 584 KBLicence: CC BY-NC-ND

Cite this

@article{8b562d3d7fd34f74be5c2bd976386018,

title = "Alzheimer's disease in humans and other animals: a consequence of postreproductive life span and longevity rather than aging",

abstract = "Introduction Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes.Methods We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease.Results and Conclusions We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease.",

keywords = "Longevity, Insulin signaling, Alzheimer's pathology, Animal models, Tau, Amyloid, GSK-3",

author = "Danielle Gunn-Moore and Oksana Kaidanovich-Beilin and {Gallego Iradi}, {Maria Carolina} and Frank Gunn-Moore and Simon Lovestone",

note = "Research in the author{\textquoteright}s laboratories is supported by the NIHR, MRC, ARUK, Alzheimer{\textquoteright}s Society, Wellcome Trust and the EU",

year = "2018",

month = feb,

doi = "10.1016/j.jalz.2017.08.014",

language = "English",

volume = "14",

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journal = "Alzheimer's and Dementia",

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TY - JOUR

T1 - Alzheimer's disease in humans and other animals

T2 - a consequence of postreproductive life span and longevity rather than aging

AU - Gunn-Moore, Danielle

AU - Kaidanovich-Beilin, Oksana

AU - Gallego Iradi, Maria Carolina

AU - Gunn-Moore, Frank

AU - Lovestone, Simon

N1 - Research in the author’s laboratories is supported by the NIHR, MRC, ARUK, Alzheimer’s Society, Wellcome Trust and the EU

PY - 2018/2

Y1 - 2018/2

N2 - Introduction Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes.Methods We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease.Results and Conclusions We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease.

AB - Introduction Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes.Methods We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease.Results and Conclusions We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease.

KW - Longevity

KW - Insulin signaling

KW - Alzheimer's pathology

KW - Animal models

KW - Tau

KW - Amyloid

KW - GSK-3

U2 - 10.1016/j.jalz.2017.08.014

DO - 10.1016/j.jalz.2017.08.014

M3 - Article

SN - 1552-5260

VL - 14

SP - 195

EP - 204

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Alzheimer's disease in humans and other animals: a consequence of postreproductive life span and longevity rather than aging

Abstract

Keywords

UN SDGs

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Cite this