Allosteric modulation of Beta1 Integrin function induces lung tissue repair

Rehab Aljamal-naylor, Linda Wilson, Susan Mcintyre, Fiona Rossi, Beth Harrison, Mark Marsden, David J. Harrison

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment. We show that, in lung injury, extracellular matrix-integrin interactions are altered and this leads to signalling alteration and mechanical missensing. The missensing, secondary to matrix alteration and cell surface receptor alterations, leads to increased cellular stiffness, injury, and death. We have identified a monoclonal antibody against ?1 integrin which caused matrix remodelling and enhancement of cell survival. The antibody acts as an allosteric dual agonist/antagonist modulator of ?1 integrin. Intriguingly, this antibody reversed both functional and structural tissue injury in an animal model of degenerative disease in lung.
Original languageEnglish
Article number768720
Number of pages16
JournalAdvances in Pharmacological Sciences
Publication statusPublished - 2012


  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


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