Allelic variation in Streptococcus pneumoniae autolysin (N- Acetyl muramoyl-L-alanine amidase)

S. H. Gillespie; T. D. McHugh; H. Ayres; A. Dickens; A. Efstratiou; G. C. Whiting

Allelic variation in Streptococcus pneumoniae autolysin (N- Acetyl muramoyl-L-alanine amidase)

S. H. Gillespie^*, T. D. McHugh, H. Ayres, A. Dickens, A. Efstratiou, G. C. Whiting

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The lytA gene encoding the autolysin of Streptococcus pneumoniae may be a virulence determinant. Single-strand conformational polymorphism analysis demonstrated heterogenicity throughout the gene in clinical isolates and strains from the clonal serotypes 7 and 14. Sequence analysis of part of the choline-binding domain showed that in two isolates four amino acid substitutions occurred.

Original language	English
Pages (from-to)	3936-3938
Number of pages	3
Journal	Infection and Immunity
Volume	65
Issue number	9
Publication status	Published - 1 Oct 1997

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Allelic variation in Streptococcus pneumoniae autolysin (N- Acetyl muramoyl-L-alanine amidase)",

abstract = "The lytA gene encoding the autolysin of Streptococcus pneumoniae may be a virulence determinant. Single-strand conformational polymorphism analysis demonstrated heterogenicity throughout the gene in clinical isolates and strains from the clonal serotypes 7 and 14. Sequence analysis of part of the choline-binding domain showed that in two isolates four amino acid substitutions occurred.",

author = "Gillespie, \{S. H.\} and McHugh, \{T. D.\} and H. Ayres and A. Dickens and A. Efstratiou and Whiting, \{G. C.\}",

year = "1997",

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language = "English",

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pages = "3936--3938",

journal = "Infection and Immunity",

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publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Allelic variation in Streptococcus pneumoniae autolysin (N- Acetyl muramoyl-L-alanine amidase)

AU - Gillespie, S. H.

AU - McHugh, T. D.

AU - Ayres, H.

AU - Dickens, A.

AU - Efstratiou, A.

AU - Whiting, G. C.

PY - 1997/10/1

Y1 - 1997/10/1

N2 - The lytA gene encoding the autolysin of Streptococcus pneumoniae may be a virulence determinant. Single-strand conformational polymorphism analysis demonstrated heterogenicity throughout the gene in clinical isolates and strains from the clonal serotypes 7 and 14. Sequence analysis of part of the choline-binding domain showed that in two isolates four amino acid substitutions occurred.

AB - The lytA gene encoding the autolysin of Streptococcus pneumoniae may be a virulence determinant. Single-strand conformational polymorphism analysis demonstrated heterogenicity throughout the gene in clinical isolates and strains from the clonal serotypes 7 and 14. Sequence analysis of part of the choline-binding domain showed that in two isolates four amino acid substitutions occurred.

UR - https://www.scopus.com/pages/publications/0030884896

M3 - Article

C2 - 9284174

AN - SCOPUS:0030884896

SN - 0019-9567

VL - 65

SP - 3936

EP - 3938

JO - Infection and Immunity

JF - Infection and Immunity

IS - 9

ER -

Allelic variation in Streptococcus pneumoniae autolysin (N- Acetyl muramoyl-L-alanine amidase)

Abstract

UN SDGs

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