Allelic variation in Streptococcus pneumoniae autolysin (N- Acetyl muramoyl-L-alanine amidase)

S. H. Gillespie*, T. D. McHugh, H. Ayres, A. Dickens, A. Efstratiou, G. C. Whiting

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The lytA gene encoding the autolysin of Streptococcus pneumoniae may be a virulence determinant. Single-strand conformational polymorphism analysis demonstrated heterogenicity throughout the gene in clinical isolates and strains from the clonal serotypes 7 and 14. Sequence analysis of part of the choline-binding domain showed that in two isolates four amino acid substitutions occurred.

Original languageEnglish
Pages (from-to)3936-3938
Number of pages3
JournalInfection and Immunity
Volume65
Issue number9
Publication statusPublished - 1 Oct 1997

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