Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis

Julie Broggi, Nicolas Joubert, Vincent Aucagne, Sabine Berteina-Raboin, S Diez-Gonzalez, Steven Patrick Nolan, Dimitri Topalis, Dominique Deville-Bonne, Jan Balzarini, Johan Neyts, Graciela Andrei, Robert Snoeck, Luigi A Agrofoglio

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxycarbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.

Original languageEnglish
Pages (from-to)1391-1394
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number10-12
DOIs
Publication statusPublished - Oct 2007

Keywords

  • click chemistry
  • Huisgen cycloaddition
  • carbanucleosides
  • alkyne-azide
  • TERMINAL ALKYNES
  • CYCLOADDITIONS
  • ANALOGS

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