Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

James P. C. Coverdale, Hugo A. van den Berg, Siavash Khazaipoul, Hannah E. Bridgewater, Alan J. Stewart, Claudia A. Blindauer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
3 Downloads (Pure)


The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
Original languageEnglish
Pages (from-to)7384-7387
Number of pages4
JournalChemical Communications
Issue number53
Early online date13 Jun 2022
Publication statusPublished - 7 Jul 2022


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