Adverse respiratory effect of acute β-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials

Daniel R Morales; Catherine Miriam Jackson; Brian J Lipworth; Peter T Donnan; Bruce Guthrie

doi:10.1378/chest.13-1235

Adverse respiratory effect of acute β-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials

Daniel R Morales
, Catherine Miriam Jackson
, Brian J Lipworth
, Peter T Donnan
, Bruce Guthrie

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

β-Blockers are avoided in asthma over concerns regarding acute bronchoconstriction. Risk is greatest following acute exposure, including the potential for antagonism of β2-agonist rescue therapy.

Original language	English
Pages (from-to)	779-86
Number of pages	8
Journal	Chest
Volume	145
Issue number	4
DOIs	https://doi.org/10.1378/chest.13-1235
Publication status	Published - Apr 2014

Keywords

Adrenergic beta-Antagonists
Asthma
Forced Expiratory Volume
Humans
Randomized Controlled Trials as Topic

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title = "Adverse respiratory effect of acute β-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials",

abstract = "β-Blockers are avoided in asthma over concerns regarding acute bronchoconstriction. Risk is greatest following acute exposure, including the potential for antagonism of β2-agonist rescue therapy.",

keywords = "Adrenergic beta-Antagonists, Asthma, Forced Expiratory Volume, Humans, Randomized Controlled Trials as Topic",

author = "Morales, \{Daniel R\} and Jackson, \{Catherine Miriam\} and Lipworth, \{Brian J\} and Donnan, \{Peter T\} and Bruce Guthrie",

note = "This study was funded by a Scottish Government Chief Scientist Office Clinical Academic Fellowship, which provided research costs and support for Dr Morales [Grant CAF/11/07].",

year = "2014",

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doi = "10.1378/chest.13-1235",

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volume = "145",

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AU - Morales, Daniel R

AU - Jackson, Catherine Miriam

AU - Lipworth, Brian J

AU - Donnan, Peter T

AU - Guthrie, Bruce

N1 - This study was funded by a Scottish Government Chief Scientist Office Clinical Academic Fellowship, which provided research costs and support for Dr Morales [Grant CAF/11/07].

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N2 - β-Blockers are avoided in asthma over concerns regarding acute bronchoconstriction. Risk is greatest following acute exposure, including the potential for antagonism of β2-agonist rescue therapy.

AB - β-Blockers are avoided in asthma over concerns regarding acute bronchoconstriction. Risk is greatest following acute exposure, including the potential for antagonism of β2-agonist rescue therapy.

KW - Adrenergic beta-Antagonists

KW - Asthma

KW - Forced Expiratory Volume

KW - Humans

KW - Randomized Controlled Trials as Topic

U2 - 10.1378/chest.13-1235

DO - 10.1378/chest.13-1235

M3 - Article

C2 - 24202435

SN - 0012-3692

VL - 145

SP - 779

EP - 786

JO - Chest

JF - Chest

IS - 4

ER -

Adverse respiratory effect of acute β-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials

Abstract

Keywords

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