Advancing stem cell technologies for conservation of wildlife biodiversity

Ashlee M. Hutchinson; Ruth Appeltant; Tom Burdon; Qiuye Bao; Rhishikesh Bargaje; Andrea Bodnar; Stuart Chambers; Pierre Comizzoli; Laura Cook; Yoshinori Endo; Bob Harman; Katsuhiko Hayashi; Thomas Hildebrandt; Marisa L. Korody; Uma Lakshmipathy; Jeanne F. Loring; Clara Munger; Alex H. M. Ng; Ben Novak; Manabu Onuma; Sara Ord; Monique Paris; Andrew J. Pask; Francisco Pelegri; Martin Pera; Ryan Phelan; Benyamin Rosental; Oliver A. Ryder; Woranop Sukparangsi; Gareth Sullivan; Nicole Liling Tay; Nikki Traylor-Knowles; Shawn Walker; Antonia Weberling; Deanne J. Whitworth; Suzannah A. Williams; Jessye Wojtusik; Jun Wu; Qi-Long Ying; Thomas P. Zwaka; Timo N. Kohler

doi:10.1242/dev.203116

Advancing stem cell technologies for conservation of wildlife biodiversity

Ashlee M. Hutchinson, Ruth Appeltant, Tom Burdon, Qiuye Bao, Rhishikesh Bargaje, Andrea Bodnar, Stuart Chambers, Pierre Comizzoli, Laura Cook, Yoshinori Endo, Bob Harman, Katsuhiko Hayashi, Thomas Hildebrandt, Marisa L. Korody, Uma Lakshmipathy, Jeanne F. Loring, Clara Munger, Alex H. M. Ng, Ben Novak, Manabu OnumaSara Ord, Monique Paris, Andrew J. Pask, Francisco Pelegri, Martin Pera, Ryan Phelan, Benyamin Rosental, Oliver A. Ryder, Woranop Sukparangsi, Gareth Sullivan, Nicole Liling Tay, Nikki Traylor-Knowles, Shawn Walker, Antonia Weberling, Deanne J. Whitworth, Suzannah A. Williams, Jessye Wojtusik, Jun Wu, Qi-Long Ying, Thomas P. Zwaka, Timo N. Kohler^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Wildlife biodiversity is essential for healthy, resilient and sustainable ecosystems. For biologists, this diversity also represents a treasure trove of genetic, molecular and developmental mechanisms that deepen our understanding of the origins and rules of life. However, the rapid decline in biodiversity reported recently foreshadows a potentially catastrophic collapse of many important ecosystems and the associated irreversible loss of many forms of life on our planet. Immediate action by conservationists of all stripes is required to avert this disaster. In this Spotlight, we draw together insights and proposals discussed at a recent workshop hosted by Revive & Restore, which gathered experts to discuss how stem cell technologies can support traditional conservation techniques and help protect animal biodiversity. We discuss reprogramming, in vitro gametogenesis, disease modelling and embryo modelling, and we highlight the prospects for leveraging stem cell technologies beyond mammalian species.

Original language	English
Article number	dev203116
Number of pages	9
Journal	Development
Volume	151
Issue number	20
Early online date	9 Oct 2024
DOIs	https://doi.org/10.1242/dev.203116
Publication status	Published - Oct 2024

Keywords

IPSC
Conservation
Biodiversity
Stem cells
Disease modelling
In vitro gametogenesis

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10.1242/dev.203116Licence: CC BY

Hutchinson-2024-Advancing-stem-cell-151-20-dev203116-CCBY
Copyright © 2024. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Final published version, 804 KBLicence: CC BY

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Hutchinson, A. M., Appeltant, R., Burdon, T., Bao, Q., Bargaje, R., Bodnar, A., Chambers, S., Comizzoli, P., Cook, L., Endo, Y., Harman, B., Hayashi, K., Hildebrandt, T., Korody, M. L., Lakshmipathy, U., Loring, J. F., Munger, C., Ng, A. H. M., Novak, B., ... Kohler, T. N. (2024). Advancing stem cell technologies for conservation of wildlife biodiversity. Development, 151(20), Article dev203116. https://doi.org/10.1242/dev.203116

@article{b3297993b72f4e93be319854189dfa9d,

title = "Advancing stem cell technologies for conservation of wildlife biodiversity",

abstract = "Wildlife biodiversity is essential for healthy, resilient and sustainable ecosystems. For biologists, this diversity also represents a treasure trove of genetic, molecular and developmental mechanisms that deepen our understanding of the origins and rules of life. However, the rapid decline in biodiversity reported recently foreshadows a potentially catastrophic collapse of many important ecosystems and the associated irreversible loss of many forms of life on our planet. Immediate action by conservationists of all stripes is required to avert this disaster. In this Spotlight, we draw together insights and proposals discussed at a recent workshop hosted by Revive & Restore, which gathered experts to discuss how stem cell technologies can support traditional conservation techniques and help protect animal biodiversity. We discuss reprogramming, in vitro gametogenesis, disease modelling and embryo modelling, and we highlight the prospects for leveraging stem cell technologies beyond mammalian species.",

keywords = "IPSC, Conservation, Biodiversity, Stem cells, Disease modelling, In vitro gametogenesis",

author = "Hutchinson, {Ashlee M.} and Ruth Appeltant and Tom Burdon and Qiuye Bao and Rhishikesh Bargaje and Andrea Bodnar and Stuart Chambers and Pierre Comizzoli and Laura Cook and Yoshinori Endo and Bob Harman and Katsuhiko Hayashi and Thomas Hildebrandt and Korody, {Marisa L.} and Uma Lakshmipathy and Loring, {Jeanne F.} and Clara Munger and Ng, {Alex H. M.} and Ben Novak and Manabu Onuma and Sara Ord and Monique Paris and Pask, {Andrew J.} and Francisco Pelegri and Martin Pera and Ryan Phelan and Benyamin Rosental and Ryder, {Oliver A.} and Woranop Sukparangsi and Gareth Sullivan and Tay, {Nicole Liling} and Nikki Traylor-Knowles and Shawn Walker and Antonia Weberling and Whitworth, {Deanne J.} and Williams, {Suzannah A.} and Jessye Wojtusik and Jun Wu and Qi-Long Ying and Zwaka, {Thomas P.} and Kohler, {Timo N.}",

note = "Funding: Open access funding provided by University of Cambridge.",

year = "2024",

month = oct,

doi = "10.1242/dev.203116",

language = "English",

volume = "151",

journal = "Development",

issn = "0950-1991",

publisher = "Company of Biologists Ltd",

number = "20",

}

Hutchinson, AM, Appeltant, R, Burdon, T, Bao, Q, Bargaje, R, Bodnar, A, Chambers, S, Comizzoli, P, Cook, L, Endo, Y, Harman, B, Hayashi, K, Hildebrandt, T, Korody, ML, Lakshmipathy, U, Loring, JF, Munger, C, Ng, AHM, Novak, B, Onuma, M, Ord, S, Paris, M, Pask, AJ, Pelegri, F, Pera, M, Phelan, R, Rosental, B, Ryder, OA, Sukparangsi, W, Sullivan, G, Tay, NL, Traylor-Knowles, N, Walker, S, Weberling, A, Whitworth, DJ, Williams, SA, Wojtusik, J, Wu, J, Ying, Q-L, Zwaka, TP & Kohler, TN 2024, 'Advancing stem cell technologies for conservation of wildlife biodiversity', Development, vol. 151, no. 20, dev203116. https://doi.org/10.1242/dev.203116

TY - JOUR

T1 - Advancing stem cell technologies for conservation of wildlife biodiversity

AU - Hutchinson, Ashlee M.

AU - Appeltant, Ruth

AU - Burdon, Tom

AU - Bao, Qiuye

AU - Bargaje, Rhishikesh

AU - Bodnar, Andrea

AU - Chambers, Stuart

AU - Comizzoli, Pierre

AU - Cook, Laura

AU - Endo, Yoshinori

AU - Harman, Bob

AU - Hayashi, Katsuhiko

AU - Hildebrandt, Thomas

AU - Korody, Marisa L.

AU - Lakshmipathy, Uma

AU - Loring, Jeanne F.

AU - Munger, Clara

AU - Ng, Alex H. M.

AU - Novak, Ben

AU - Onuma, Manabu

AU - Ord, Sara

AU - Paris, Monique

AU - Pask, Andrew J.

AU - Pelegri, Francisco

AU - Pera, Martin

AU - Phelan, Ryan

AU - Rosental, Benyamin

AU - Ryder, Oliver A.

AU - Sukparangsi, Woranop

AU - Sullivan, Gareth

AU - Tay, Nicole Liling

AU - Traylor-Knowles, Nikki

AU - Walker, Shawn

AU - Weberling, Antonia

AU - Whitworth, Deanne J.

AU - Williams, Suzannah A.

AU - Wojtusik, Jessye

AU - Wu, Jun

AU - Ying, Qi-Long

AU - Zwaka, Thomas P.

AU - Kohler, Timo N.

N1 - Funding: Open access funding provided by University of Cambridge.

PY - 2024/10

Y1 - 2024/10

N2 - Wildlife biodiversity is essential for healthy, resilient and sustainable ecosystems. For biologists, this diversity also represents a treasure trove of genetic, molecular and developmental mechanisms that deepen our understanding of the origins and rules of life. However, the rapid decline in biodiversity reported recently foreshadows a potentially catastrophic collapse of many important ecosystems and the associated irreversible loss of many forms of life on our planet. Immediate action by conservationists of all stripes is required to avert this disaster. In this Spotlight, we draw together insights and proposals discussed at a recent workshop hosted by Revive & Restore, which gathered experts to discuss how stem cell technologies can support traditional conservation techniques and help protect animal biodiversity. We discuss reprogramming, in vitro gametogenesis, disease modelling and embryo modelling, and we highlight the prospects for leveraging stem cell technologies beyond mammalian species.

AB - Wildlife biodiversity is essential for healthy, resilient and sustainable ecosystems. For biologists, this diversity also represents a treasure trove of genetic, molecular and developmental mechanisms that deepen our understanding of the origins and rules of life. However, the rapid decline in biodiversity reported recently foreshadows a potentially catastrophic collapse of many important ecosystems and the associated irreversible loss of many forms of life on our planet. Immediate action by conservationists of all stripes is required to avert this disaster. In this Spotlight, we draw together insights and proposals discussed at a recent workshop hosted by Revive & Restore, which gathered experts to discuss how stem cell technologies can support traditional conservation techniques and help protect animal biodiversity. We discuss reprogramming, in vitro gametogenesis, disease modelling and embryo modelling, and we highlight the prospects for leveraging stem cell technologies beyond mammalian species.

KW - IPSC

KW - Conservation

KW - Biodiversity

KW - Stem cells

KW - Disease modelling

KW - In vitro gametogenesis

U2 - 10.1242/dev.203116

DO - 10.1242/dev.203116

M3 - Review article

SN - 0950-1991

VL - 151

JO - Development

JF - Development

IS - 20

M1 - dev203116

ER -

Advancing stem cell technologies for conservation of wildlife biodiversity

Abstract

Keywords

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