"Adaptive response" - some underlying mechanisms and open questions

Evgeniya G Dimova, Peter Edward Bryant, Stephka G Chankova

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)
1 Downloads (Pure)

Abstract

Organisms are affected by different DNA damaging agents naturally present in the environment or released as a result of human activity. Many defense mechanisms have evolved in organisms to minimize genotoxic damage. One of them is induced radioresistance or adaptive response. The adaptive response could be considered as a nonspecific phenomenon in which exposure to minimal stress could result in increased resistance to higher levels of the same or to other types of stress some hours later. A better understanding of the molecular mechanism underlying the adaptive response may lead to an improvement of cancer treatment, risk assessment and risk management strategies, radiation protection, e. g. of astronauts during long-term space flights. In this mini-review we discuss some open questions and the probable underlying mechanisms involved in adaptive response: the transcription of many genes and the activation of numerous signaling pathways that trigger cell defenses - DNA repair systems, induction of proteins synthesis, enhanced detoxification of free radicals and antioxidant production.

Original languageEnglish
Pages (from-to)396-408
Number of pages13
JournalGenetics and Molecular Biology
Volume31
Issue number2
DOIs
Publication statusPublished - 2008

Keywords

  • Adaptive response
  • Oxidative stress
  • DNA repair up-regulation
  • DNA-binding proteins
  • Antioxidant defense system
  • Low-dose radiation
  • Peripheral-blood lympPEROXIDE INDUCES PROTECTIONhocytes
  • Peroxide induces protection
  • Methyl mercuric-chloride
  • Double-strand breaks
  • Nuclear-power-plant
  • Induced DNA-damage
  • Hamster V79 cells
  • Ionizing-radiation
  • Chlamydomonas-reinhardtii

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