Activity of moxifloxacin against mycobacteria

S. H. Gillespie; O. Billington

doi:10.1093/jac/44.3.393

Activity of moxifloxacin against mycobacteria

S. H. Gillespie^*, O. Billington

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Moxifloxacin is an 8-methoxyquinolone compound with activity against a wide range of bacteria. We tested its activity in comparison with four other quinolones and isoniazid against clinical isolates of mycobacteria. It proved to be the most active of the quinolones tested against Mycobacterium tuberculosis (MIC₉₀ 0.25 mg/L), Mycobacterium avium-intracellulare (MIC₉₀ 1.0 mg/L), Mycobacterium kansasii (MIC₉₀ 0.06 mg/L) and Mycobacterium fortuitum (MIC₉₀ 1 mg/L). These data indicate that moxifloxacin merits further study as an antimycobacterial agent.

Original language	English
Pages (from-to)	393-395
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	44
Issue number	3
DOIs	https://doi.org/10.1093/jac/44.3.393
Publication status	Published - 20 Sept 1999

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SDG 3 Good Health and Well-being

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10.1093/jac/44.3.393

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title = "Activity of moxifloxacin against mycobacteria",

abstract = "Moxifloxacin is an 8-methoxyquinolone compound with activity against a wide range of bacteria. We tested its activity in comparison with four other quinolones and isoniazid against clinical isolates of mycobacteria. It proved to be the most active of the quinolones tested against Mycobacterium tuberculosis (MIC90 0.25 mg/L), Mycobacterium avium-intracellulare (MIC90 1.0 mg/L), Mycobacterium kansasii (MIC90 0.06 mg/L) and Mycobacterium fortuitum (MIC90 1 mg/L). These data indicate that moxifloxacin merits further study as an antimycobacterial agent.",

author = "Gillespie, \{S. H.\} and O. Billington",

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doi = "10.1093/jac/44.3.393",

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AU - Gillespie, S. H.

AU - Billington, O.

PY - 1999/9/20

Y1 - 1999/9/20

N2 - Moxifloxacin is an 8-methoxyquinolone compound with activity against a wide range of bacteria. We tested its activity in comparison with four other quinolones and isoniazid against clinical isolates of mycobacteria. It proved to be the most active of the quinolones tested against Mycobacterium tuberculosis (MIC90 0.25 mg/L), Mycobacterium avium-intracellulare (MIC90 1.0 mg/L), Mycobacterium kansasii (MIC90 0.06 mg/L) and Mycobacterium fortuitum (MIC90 1 mg/L). These data indicate that moxifloxacin merits further study as an antimycobacterial agent.

AB - Moxifloxacin is an 8-methoxyquinolone compound with activity against a wide range of bacteria. We tested its activity in comparison with four other quinolones and isoniazid against clinical isolates of mycobacteria. It proved to be the most active of the quinolones tested against Mycobacterium tuberculosis (MIC90 0.25 mg/L), Mycobacterium avium-intracellulare (MIC90 1.0 mg/L), Mycobacterium kansasii (MIC90 0.06 mg/L) and Mycobacterium fortuitum (MIC90 1 mg/L). These data indicate that moxifloxacin merits further study as an antimycobacterial agent.

UR - https://www.scopus.com/pages/publications/0032870624

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DO - 10.1093/jac/44.3.393

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SP - 393

EP - 395

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 3

ER -

Activity of moxifloxacin against mycobacteria

Abstract

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