Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin

P. H.M. McWhinney; S. Patel; R. A. Whiley; J. M. Hardie; S. H. Gillespie; C. C. Kibbler

doi:10.1128/AAC.37.11.2493

Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin

P. H.M. McWhinney^*
, S. Patel
, R. A. Whiley
, J. M. Hardie
, S. H. Gillespie
, C. C. Kibbler

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC₅₀], 0.125 μg/ml) and ceftazidime (MIC₅₀, 4 μg/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC₉₀ of sparfloxacin was 1 μg/ml; those for ciprofloxacin and ofloxacin were >16 and 16 μg/ml, respectively.

Original language	English
Pages (from-to)	2493-2495
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	37
Issue number	11
DOIs	https://doi.org/10.1128/AAC.37.11.2493
Publication status	Published - 1 Jan 1993

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McWhinney, P. H. M., Patel, S., Whiley, R. A., Hardie, J. M., Gillespie, S. H., & Kibbler, C. C. (1993). Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin. Antimicrobial Agents and Chemotherapy, 37(11), 2493-2495. https://doi.org/10.1128/AAC.37.11.2493

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title = "Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin",

abstract = "All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50\% of isolates [MIC50], 0.125 μg/ml) and ceftazidime (MIC50, 4 μg/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 μg/ml; those for ciprofloxacin and ofloxacin were >16 and 16 μg/ml, respectively.",

author = "McWhinney, \{P. H.M.\} and S. Patel and Whiley, \{R. A.\} and Hardie, \{J. M.\} and Gillespie, \{S. H.\} and Kibbler, \{C. C.\}",

year = "1993",

month = jan,

day = "1",

doi = "10.1128/AAC.37.11.2493",

language = "English",

volume = "37",

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journal = "Antimicrobial Agents and Chemotherapy",

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}

McWhinney, PHM, Patel, S, Whiley, RA, Hardie, JM, Gillespie, SH & Kibbler, CC 1993, 'Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin', Antimicrobial Agents and Chemotherapy, vol. 37, no. 11, pp. 2493-2495. https://doi.org/10.1128/AAC.37.11.2493

Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin. / McWhinney, P. H.M.; Patel, S.; Whiley, R. A. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 37, No. 11, 01.01.1993, p. 2493-2495.

Research output: Contribution to journal › Comment/debate › peer-review

TY - JOUR

T1 - Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin

AU - McWhinney, P. H.M.

AU - Patel, S.

AU - Whiley, R. A.

AU - Hardie, J. M.

AU - Gillespie, S. H.

AU - Kibbler, C. C.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 μg/ml) and ceftazidime (MIC50, 4 μg/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 μg/ml; those for ciprofloxacin and ofloxacin were >16 and 16 μg/ml, respectively.

AB - All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 μg/ml) and ceftazidime (MIC50, 4 μg/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 μg/ml; those for ciprofloxacin and ofloxacin were >16 and 16 μg/ml, respectively.

UR - https://www.scopus.com/pages/publications/0027435085

U2 - 10.1128/AAC.37.11.2493

DO - 10.1128/AAC.37.11.2493

M3 - Comment/debate

C2 - 8285642

AN - SCOPUS:0027435085

SN - 0066-4804

VL - 37

SP - 2493

EP - 2495

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin

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