Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin

P. H.M. McWhinney*, S. Patel, R. A. Whiley, J. M. Hardie, S. H. Gillespie, C. C. Kibbler

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

55 Citations (Scopus)

Abstract

All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 μg/ml) and ceftazidime (MIC50, 4 μg/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 μg/ml; those for ciprofloxacin and ofloxacin were >16 and 16 μg/ml, respectively.

Original languageEnglish
Pages (from-to)2493-2495
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume37
Issue number11
DOIs
Publication statusPublished - 1 Jan 1993

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