TY - JOUR
T1 - Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin
AU - McWhinney, P. H.M.
AU - Patel, S.
AU - Whiley, R. A.
AU - Hardie, J. M.
AU - Gillespie, S. H.
AU - Kibbler, C. C.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 μg/ml) and ceftazidime (MIC50, 4 μg/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 μg/ml; those for ciprofloxacin and ofloxacin were >16 and 16 μg/ml, respectively.
AB - All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 μg/ml) and ceftazidime (MIC50, 4 μg/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 μg/ml; those for ciprofloxacin and ofloxacin were >16 and 16 μg/ml, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0027435085&partnerID=8YFLogxK
U2 - 10.1128/AAC.37.11.2493
DO - 10.1128/AAC.37.11.2493
M3 - Comment/debate
C2 - 8285642
AN - SCOPUS:0027435085
SN - 0066-4804
VL - 37
SP - 2493
EP - 2495
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 11
ER -
