Active natural product scaffolds against trypanosomatid parasites: a review

Peter E. Cockram, Terry K. Smith*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

Neglected tropical diseases caused by trypanosomatid parasites are a continuing and escalating problem, which devastate the less economically developed cultures in countries in which they are endemic by impairing both human and animal health. Current drugs for these diseases are regarded as out-of-date and expensive, with unacceptable side-effects and mounting parasite resistance, meaning there is an urgent need for new therapeutics. Natural products have long been a source of potent, structurally diverse bioactive molecules. Herein are reviewed natural products with reported trypanocidal activity, which have been clustered based on core structural similarities, to aid the future discovery of new trypanocidal core motifs with potential routes to synthetically accessible natural product cores suggested.

Original languageEnglish
Pages (from-to)2138-2154
JournalJournal of Natural Products
Volume81
Issue number9
Early online date20 Sept 2018
DOIs
Publication statusPublished - 28 Sept 2018

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