Accurate lipophilicity (log P) measurements inform on subtle stereoelectronic effects in fluorine chemistry

David O'Hagan; Robert J. Young

doi:10.1002/anie.201511055

Accurate lipophilicity (log P) measurements inform on subtle stereoelectronic effects in fluorine chemistry

David O'Hagan^*, Robert J. Young

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

Abstract

Polar exploration: Recently, Linclau and co-workers disclosed a straightforward ¹⁹F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.

Original language	English
Pages (from-to)	3858-3860
Number of pages	3
Journal	Angewandte Chemie International Edition
Volume	55
Issue number	12
Early online date	19 Feb 2016
DOIs	https://doi.org/10.1002/anie.201511055
Publication status	Published - 14 Mar 2016

Keywords

Fluorine
Fluorocarbons
Lipophilicity
NMR spectroscopy

Access to Document

10.1002/anie.201511055

Novel organofluorine motifs: Novel organofluorine motifs in the service of industry
O'Hagan, D. (PI)
EPSRC
1/03/14 → 28/02/17
Project: Standard

Cite this

@article{26d74bc325014192bdb32ed0795b56db,

title = "Accurate lipophilicity (log P) measurements inform on subtle stereoelectronic effects in fluorine chemistry",

abstract = "Polar exploration: Recently, Linclau and co-workers disclosed a straightforward 19F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.",

keywords = "Fluorine, Fluorocarbons, Lipophilicity, NMR spectroscopy",

author = "David O'Hagan and Young, {Robert J.}",

year = "2016",

month = mar,

day = "14",

doi = "10.1002/anie.201511055",

language = "English",

volume = "55",

pages = "3858--3860",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

publisher = "John Wiley & Sons, Ltd",

number = "12",

}

TY - JOUR

T1 - Accurate lipophilicity (log P) measurements inform on subtle stereoelectronic effects in fluorine chemistry

AU - O'Hagan, David

AU - Young, Robert J.

PY - 2016/3/14

Y1 - 2016/3/14

N2 - Polar exploration: Recently, Linclau and co-workers disclosed a straightforward 19F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.

AB - Polar exploration: Recently, Linclau and co-workers disclosed a straightforward 19F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.

KW - Fluorine

KW - Fluorocarbons

KW - Lipophilicity

KW - NMR spectroscopy

U2 - 10.1002/anie.201511055

DO - 10.1002/anie.201511055

M3 - Short survey

AN - SCOPUS:84975706914

SN - 1433-7851

VL - 55

SP - 3858

EP - 3860

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 12

ER -

Accurate lipophilicity (log P) measurements inform on subtle stereoelectronic effects in fluorine chemistry

Abstract

Keywords

Access to Document

Fingerprint

Projects

Novel organofluorine motifs: Novel organofluorine motifs in the service of industry

Cite this