Accurate lipophilicity (log P) measurements inform on subtle stereoelectronic effects in fluorine chemistry

David O'Hagan*, Robert J. Young

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

18 Citations (Scopus)

Abstract

Polar exploration: Recently, Linclau and co-workers disclosed a straightforward 19F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.

Original languageEnglish
Pages (from-to)3858-3860
Number of pages3
JournalAngewandte Chemie International Edition
Volume55
Issue number12
Early online date19 Feb 2016
DOIs
Publication statusPublished - 14 Mar 2016

Keywords

  • Fluorine
  • Fluorocarbons
  • Lipophilicity
  • NMR spectroscopy

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