Accurate extraction of nanometer distances in multimers by pulse EPR

Silvia Valera, Katrin Ackermann, Christos Pliotas, Hexian Huang, James Henderson Naismith, Bela Ernest Bode

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Pulse electron paramagnetic resonance (EPR) is gaining increasing importance in
structural biology. The PELDOR (pulsed electron-electron double resonance) method allows extracting distance information on the nanometer scale. Here, we demonstrate the efficient extraction of distances from multimeric systems such as membrane embedded ion channels where data analysis is commonly hindered by multi-spin effects.
Original languageEnglish
Pages (from-to)4700–4703
JournalChemistry - A European Journal
Volume22
Issue number14
Early online date25 Feb 2016
DOIs
Publication statusPublished - 16 Mar 2016

Keywords

  • Biomimetic synthesis
  • Deer
  • EPR spectroscopy
  • Ion channels
  • Mambrane proteins
  • Structural biology

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