Projects per year
Abstract
The N-butyl amide group, CONHBu, has been found to be an effective promoter of the [1,2]-Wittig rearrangement of aryl benzyl ethers and thus allow the two-step synthesis of isomerically-pure substituted diarylmethanols starting from simple hydroxybenzoic acid derivatives. The method is compatible with a wide range of functional groups including methyl, methoxy and fluoro, although not with nitro and, unexpectedly, is applicable to meta as well as ortho and para isomeric series.
Original language | English |
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Pages (from-to) | 4692-4701 |
Number of pages | 10 |
Journal | The Journal of Organic Chemistry |
Volume | 87 |
Issue number | 7 |
Early online date | 14 Mar 2022 |
DOIs | |
Publication status | Published - 13 Apr 2022 |
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Dive into the research topics of 'Access to diarylmethanols by Wittig rearrangement of ortho-, meta- and para-benzyloxy-N-butylbenzamides'. Together they form a unique fingerprint.Projects
- 1 Finished
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CRITICAT CDT: Critical Resource Catalysis - CRITICAT
Smith, A. D. (PI), Nolan, S. P. (CoI) & Westwood, N. J. (CoI)
1/05/14 → 31/10/22
Project: Standard
Datasets
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CCDC 2105490 - 2105493: Experimental Crystal Structure Determination
Aitken, R. A. (Creator), Harper, A. D. (Creator), Inwood, R. (Creator) & Slawin, A. M. Z. (Creator), The Cambridge Structural Database, 25 Aug 2021
DOI: 10.5517/ccdc.csd.cc28ny1y, https://dx.doi.org/10.5517/ccdc.csd.cc28ny2z and 2 more links, https://dx.doi.org/10.5517/ccdc.csd.cc28ny30, https://dx.doi.org/10.5517/ccdc.csd.cc28ny41 (show fewer)
Dataset