Accelerating influence of the gem-difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe–Ingold effect?

César Alejandro Urbina Blanco, Maciej Skibinski, David O'Hagan, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The gem-difluoromethylene (CF2) group significantly accelerates
ring-closing metathesis of 1,8-nonadienes relative to the methylene
(CH2) group demonstrating similar rate accelerations to that observed
for the classic Thorpe–Ingold substituents, diester malonates and ketals.
Original languageEnglish
Pages (from-to)7201-7203
Number of pages3
JournalChemical Communications
Volume49
Issue number65
Early online date4 Jul 2013
DOIs
Publication statusPublished - 21 Aug 2013

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