A Y chromosomal influence on prostate cancer risk: The multi-ethnic cohort study

S. Paracchini; C. L. Pearce; L. N. Kolonel; D. Altshuler; B. E. Henderson; C. Tyler-Smith

A Y chromosomal influence on prostate cancer risk: The multi-ethnic cohort study

S. Paracchini, C. L. Pearce, L. N. Kolonel, D. Altshuler, B. E. Henderson, C. Tyler-Smith^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background: A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. Methods: We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. Results: One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). Conclusions: This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.

Original language	English
Pages (from-to)	815-819
Number of pages	5
Journal	Journal of Medical Genetics
Volume	40
Issue number	11
Publication status	Published - 1 Nov 2003

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title = "A Y chromosomal influence on prostate cancer risk: The multi-ethnic cohort study",

abstract = "Background: A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. Methods: We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. Results: One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). Conclusions: This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.",

author = "S. Paracchini and Pearce, {C. L.} and Kolonel, {L. N.} and D. Altshuler and Henderson, {B. E.} and C. Tyler-Smith",

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T1 - A Y chromosomal influence on prostate cancer risk

T2 - The multi-ethnic cohort study

AU - Paracchini, S.

AU - Pearce, C. L.

AU - Kolonel, L. N.

AU - Altshuler, D.

AU - Henderson, B. E.

AU - Tyler-Smith, C.

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Background: A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. Methods: We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. Results: One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). Conclusions: This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.

AB - Background: A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. Methods: We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. Results: One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). Conclusions: This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.

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A Y chromosomal influence on prostate cancer risk: The multi-ethnic cohort study

Abstract

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