A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer

T Gloster, S J Williams, C A Tarling, S Roberts, C Dupont, P Jodoin, F Shareck, S G Withers, G J Davies

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid-base.

Original languageEnglish
Pages (from-to)944-945
Number of pages2
JournalChemical Communications
Issue number8
DOIs
Publication statusPublished - 2003

Keywords

  • KINETIC-ANALYSIS

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