A three-component tandem reductive aldol reaction catalyzed by N-heterocyclic carbene-copper complexes

Alexandre Welle, Silvia Diez-Gonzalez, Bernard Tinant, Steven Patrick Nolan, Olivier Riant

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

An efficient catalytic system for the three-component coupling of electrophilic alkenes, aldehydes, and silane was optimized with a new family of copper N-heterocyclic carbene complexes. These catalysts do not require activation and show high activity (TOF > 15 000 h(-1)) as well as some anti diastereoselectivity.

Original languageEnglish
Pages (from-to)6059-6062
Number of pages4
JournalOrganic Letters
Volume8
Issue number26
DOIs
Publication statusPublished - 21 Dec 2006

Keywords

  • CONJUGATE ADDITION
  • ENANTIOSELECTIVE SYNTHESIS
  • CARBONYL-COMPOUNDS
  • ASYMMETRIC-SYNTHESIS
  • GRIGNARD-REAGENTS
  • STRYKERS REAGENT
  • CYCLIZATION
  • KETONES
  • NHC
  • HYDROSILYLATION

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